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We are a worldwide social network of freethinkers, atheists, agnostics and secular humanists.

To Meth-Heads, LSD users, Marijuana Users, especcially those who combine it with opieates...Your Days are Numbered!

All Drug users who find it so convenient to tell the rest of us that your perversion is natural.... I have a suggestion for you....

'Eat Shit and then Die!"   You Are all Insane.  Thanks, Joey!

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Comment by Chris on February 13, 2019 at 10:59am

Epiphrine auto-injector.

Years after Mylan’s epic EpiPen price hikes, it finally gets a gene...

Mylan’s life-saving epinephrine auto-injector EpiPen now has a generic rival, the Food and Drug Administration triumphantly announced.

Teva Pharmaceuticals USA now has FDA approval to market a direct generic competitor of the device, as well as a version for pediatric patients, a generic EpiPen Jr. Both products are used in emergency situations to auto-inject a dose of epinephrine into a person’s thigh to thwart deadly allergic reactions, namely anaphylactic shock.

The approval comes years after Mylan outraged patients and lawmakers by ruthlessly hiking the price of its product by more than 400 percent. Mylan purchased the rights to EpiPen in 2007 and gradually raised the list price from about $50 per auto-injector to slightly over $600 for a two-pack. The move boosted EpiPen profits to $1.1 billion a year. In step, Mylan CEO Heather Bresch saw her salary soar by millions, reaching nearly $19 million in 2015—a point lawmakers hammered her for during a House Oversight Committee hearing in September of 2016.

Amid the intense scrutiny, Mylan announced that it would release its own “authorized generic” version of the EpiPen. But the product debuted with a list price of $300 per two-pack, still triple the price of what the product cost prior to Mylan’s 2007 takeover.

Epinephrine alone is already a generic drug, and the dose in an auto-injector costs less than a dollar to make. But the EpiPen is a drug-device “combination product,” which has been tricky for rivals to replicate exactly in order to get FDA approval. Mylan has also been accused by fellow pharmaceutical companies of trying to squash rivals.

In 2009, Mylan had Teva sued for patent infringement, leading to a settlement that kept Teva off the EpiPen market until 2015. Then, in 2016, the FDA found “major deficiencies” in Teva’s application to market a rival EpiPen generic. Since then, other makers have made different types of epinephrine auto-injectors, most notably Adrenaclick and the pricy Auvi-Q, but they work differently from EpiPen and can’t be used interchangeably like a generic version.

Teva’s long-sought generic now offers patients that option—and the potential for lower prices.

In a statement, FDA Commissioner Scott Gottlieb trumpeted the approval as a win in the effort to drag down skyrocketing drug costs:

Today’s approval of the first generic version of the most-widely prescribed epinephrine auto-injector in the U.S. is part of our longstanding commitment to advance access to lower cost, safe and effective generic alternatives once patents and other exclusivities no longer prevent approval.

Still, Teva has yet to name the price of its generic, ensuring that the FDA’s hopes are indeed true. Two Teva spokespeople declined to reveal any hints on the device’s list price to Ars. They only provided a written statement:

Today’s approval of our generic version of EpiPen(epinephrine injection, USP) Auto-Injector 0.3 mg and 0.15 mg in the US marks an important step forward in bringing patients additional prescription medications that have met the FDA’s rigorous standards.

We’re applying our full resources to this important launch in the coming months and eager to begin supplying the market.

Once launched, Teva’s product will be the only generic, AB-rated/therapeutically equivalent version of EpiPen.

______

A while back I read a PEW poll asking which department of the government would you like to diminish. After explination of each department most said the departments are a value to the country.

The FDA and EPA for example.

Comment by Chris on February 13, 2019 at 10:40am

Even coca leaves beforre being processed with all the chemicals into cocaine are good for high altitudes, and stamina.

Like coffee.

I agree as terrible as herion may be - especially spiced with fentanyl.

Looking at this China is the biggest producer of fentanyl. India is the biggest producer of pseudeophedrine used for meth.

Spice -synthetic marijuana (AKA bath salts)  - the laws are unable to keep up with it..
Comment by Chris on February 13, 2019 at 10:18am

As a side note the first birth controll pill was formulated from a sweet potato.

Asprin (aceliclic acid) if developed today would be a perscription.

http://www.cnn.com/2010/HEALTH/12/22/aspirin.history/index.html

From a tree, a 'miracle' called aspirin

(CNN) -- If you take aspirin, you've got a pain reliever, heart attack preventer and possible cancer preventer rolled into one tablet. You might think that whoever invented aspirin is a genius, but the truth is humans have been using its natural equivalent for thousands of years.

"Aspirin is one of those things that, long before there were ever clinical trials or any kind of scientific knowledge, people figured out, 'Hey, I feel better when I take this substance,' " said Dr. Karol Watson, assistant professor of cardiology at the David Geffen School of Medicine at the University of California, Los Angeles.

The drug has been making headlines because a study in the Lancet recently found that a daily aspirin appeared to lower the risk of cancer by at least 20% during a 20-year period. That's based on data from more than 25,000 patients and builds on earlier findings that aspirin may lower the risk of colorectal cancer. The research has limitations and is not definitive proof, but it does add another benefit to an ancient remedy that has been called a miracle drug.

"There are no countries in which it is unknown, unappreciated, or unavailable," the late medical writer Berton Roueché wrote in 1955, in an article later published in the anthology "The Medical Detectives."

History of aspirin

The word "aspirin" wasn't a coincidence. It comes from Spiraea, a biological genus of shrubs that includes natural sources of the drug's key ingredient: salicylic acid. This acid, resembling what's in modern-day aspirin, can be found in jasmine, beans, peas, clover and certain grasses and trees.

The ancient Egyptians used willow bark as a remedy for aches and pains, said Diarmuid Jeffreys, author of "Aspirin: The Remarkable Story of a Wonder Drug." They didn't know that what was reducing body temperature and inflammation was the salicylic acid.

Hippocrates, the Greek physician who lived from about 460 to 377 B.C., wrote that willow leaves and bark relieved pain and fevers.

It wasn't until thousands of years later that people began to isolate the key ingredients of aspirin. An 18th-century clergyman, Edward Stone, rediscovered aspirin, in effect, when he wrote a report about how a preparation of powdered willow bark seemed to benefit 50 patients with ague and other maladies, Roueché wrote.

In the 1800s, researchers across Europe explored salicylic acid. French pharmacist Henri Leroux isolated it in 1829, Roueché writes. Hermann Kolbe discovered synthetic salicylic acid in 1874, but when administered often in large doses, patients experienced nausea and vomiting, and some even went into a coma. A buffer was needed to ease the effects of this acid on the stomach.

The aspirin we know came into being in the late 1890s in the form of acetylsalicylic acid when chemist Felix Hoffmann at Bayer in Germany used it to alleviate his father's rheumatism, a timeline from Bayer says. Beginning in 1899, Bayer distributed a powder with this ingredient to physicians to give to patients. The drug became a hit and, in 1915, it was sold as over-the-counter tablets.

One patient who should not have been taking aspirin was young Alexei Nicholaevich Romanov of Russia, who had hemophilia. Aspirin would make the bleeding in this disorder worse, but the imperial doctors likely gave the boy this new wonder drug without knowing, Jeffreys said.

Alexei, son of the last czar, probably improved because the mystic Grigori Rasputin told the boy's mother to stop modern treatments and instead rely on spiritual healing. Rasputin's influence on the Romanov family may have contributed to the uprising against them, making aspirin a possible player in their murder and in the end of czarist Russia.

Aspirin's uses for heart patients came to light in 1948 when California physician Dr. Lawrence Craven recommended an aspirin a day to reduce heart attack risk, based on what he had observed in patients.

The Nobel Prize in medicine in 1982 was awarded to researchers who demonstrated the reason -- it inhibits production of hormones called prostoglandins. Prostoglandins are responsible for the formation of clots that leads to heart attacks and strokes, and aspirin prevents that clotting from happening.

Toward better preventative medicine

Today, aspirin is universally recognized as heart-attack prevention in men who have had prior heart attacks, and it has also shown to have benefits against stroke in women.

More than one-third of all adults, and four out of five people with heart disease, use aspirin regularly, according to data from the Centers for Disease Control and Prevention presented in a 2006 study. And the number of regular aspirin users rose 20 percent from 1999 to 2003.

Still, it's not necessarily the go-to for over-the-counter painkillers. In 2007, pain relievers such as Advil, Tylenol and Aleve were among the top five analgesics sold; aspirin did not make the cut.

"If you're hurting, you're going to reach for a stronger pain reliever," Watson said. "In most cases, a baby aspirin a day is not going to make you feel any better or worse."

The U.S. Preventive Services Task Force recommends that men 49 to 79 take aspirin to prevent heart attack, and that women 55 to 79 take it to guard against ischemic strokes, when the potential benefits outweigh the potential harms from an increase in gastrointestinal hemorrhage. In other words, aspirin can increase bleeding because of decreased clotting, so if you have bleeding problems, it's not a good idea.

People who need to take aspirin because of prior heart attack can reduce the risk of stomach bleeding by taking a medication that cuts down on stomach acid like omeprazole (Prilosec), said Dr. Harvey Simon, associate professor of medicine at Harvard Medical School. Still, "we don't like people to take medicine to reduce effects of another medicine," he said.

Aspirin's potential cancer benefits have come on the scene more recently, and there aren't standard guidelines in that regard. The agency discourages taking aspirin to prevent colorectal cancer in people with average risk for that disease. Also, the mechanism isn't entirely understood, although the thought is that aspirin helps the body cut off blood supply to cancer growths, Jeffreys said.

Aspirin is in the family of nonsteroidal anti-inflammatory drugs (NSAIDs), many of which have been implicated in heart risk rather than prevention. Among the NSAIDs, the more potent pain relievers tend to carry more potential for cardiovascular damage, Watson said.

Famously, the drug rofecoxib (Vioxx) was withdrawn from the market in 2004 because of heart concerns. A recent study found that painkillers called opioids heightened heart attack risk in addition to bone fracture when compared with patients taking NSAIDs such as aspirin and ibuprofen. And research published in June found that some NSAIDs may increase risk of cardiovascular death.

Aspirin has a lot of cheerleaders, but it's important to keep the downsides in perspective. Dr. Scott Fishman, chief of pain medicine at the University of California, Davis, points out that as a pain reliever, aspirin's effects are potent but short-lived. The way that aspirin inhibits enzymes in the stomach can lead to ulcers, which can be especially harmful in combination with decreased clotting.

The drug works as a pain reliever because it blocks an enzyme that's required for the process of inflammatory response, he said.

Patients should not just take it without consulting their physicians, Fishman said. Certain conditions such as bleeding disorders make taking aspirin dangerous. Some supplements, such as fish oil and garlic, can also cause bleeding problems in combination with aspirin, he said. Aspirin is not approved for children younger than 2 and should be used with caution in very young people because of a possible link to Reye's syndrome.

Still, it's likely that aspirin has even more benefits that just haven't been discovered yet, Jeffreys said. In his view, the drug is taken for granted, and not enough emphasis is placed on it.

"If I'm stranded on a desert island, and I can take one drug with me, that's the one I'm taking," Watson said.

Comment by Chris on February 13, 2019 at 10:15am

As a side note the first birth controll pill was formulated from a sweet potato.

Asprin (aceliclic acid) if developed today would be a perscription.

http://www.cnn.com/2010/HEALTH/12/22/aspirin.history/index.html

Comment by Chris on February 13, 2019 at 10:08am

Attemps for saffron didn't work for the climate. Foolish attempt.

As you know the powers at be including the pharmicutical industry with pushing oxycotin is more dangerous than plant based 'drugs'

Comment by Chris on February 13, 2019 at 10:02am

To add the Mujideen in Afghanistan stopped herion growth.  The U.S. Army policy was to let them grow and export it to grow the economy.  I read that heroin became so prevelant in Afganistan that when someone smoked it the children, dogs, even rats and mice would gather around the smoke.

There were attempts to get them to grow saffron.

Comment by Chris on February 13, 2019 at 9:53am

One of the projects I worked on for the Navy was with the DEA to intercept drugs.

Look at the Iran Contra Affair with Noregia.  Smuggling drugs, shipping guns and laundering money for the CIA.

Ollie North is a POS as well as Ronnie with his just say no campaign- while supporting the brutal Contras while paying Noriegia.

I've looked at drugs and addiction. The only one I'm worried about is methamphetimine.  Other than that illegal drug, why should you care in a legal or moral sense about the others?

Camomile tea,  melatonin?

Comment by Stephen on February 5, 2019 at 11:03pm

That's very human of you Joey. You are full of the milk of human kindness aren't you.

Comment by Neal on February 5, 2019 at 12:12pm

This is kind of a crap post. Do you really want everyone to eat shit and die that doesn't agree with you? 

Everything is a drug, everything can kill you, everything can help you, it's all in how it's used. =)

Comment by Lutz on January 29, 2019 at 4:14am

actually they all don't do the lot you know. Those on coke don't do smack and they don't do dope and they don't do smack but would acid except in ain't around replaced by mdma which is shit.

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