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Medicine, Medical insurance Pharmaceuticals, and Medical Care (CDC and etcetera)

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Medicine, Medical insurance Pharmaceuticals, and Medical Care (CDC and etcetera)

This is a group to discuss the problems with Medicine, Medical insurance, pharmacieuticals, and Medical Care, CDC (Center for Disease Control), Medicins Sans Frontieres (Doctors Without Boarders), and etcetra.

Members: 8
Latest Activity: Nov 15

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Comment by Chris on November 12, 2016 at 4:54am

We all know this 'don't we?'

As drug industry’s influence over research grows, so does the poten...

November 24, 2012

For drugmaker GlaxoSmithKline, the 17-page article in the New England Journal of Medicine represented a coup.

The 2006 report described a trial that compared three diabetes drugs and concluded that Avandia, the company’s new drug, performed best.

“We now have clear evidence from a large international study that the initial use of [Avandia] is more effective than standard therapies,” a senior vice president of GlaxoSmithKline, Lawson Macartney, said in a news release.

What only careful readers of the article would have gleaned is the extent of the financial connections between the drugmaker and the research. The trial had been funded by GlaxoSmithKline, and each of the 11 authors had received money from the company. Four were employees and held company stock. The other seven were academic experts who had received grants or consultant fees from the firm.

Whether these ties altered the report on Avandia may be impossible for readers to know. But while sorting through the data from more than 4,000 patients, the investigators missed hints of a danger that, when fully realized four years later, would lead to Avandia’s virtual disappearance from the United States:

More in the above link including a graphic.

Comment by Chris on November 10, 2016 at 9:59pm

The FDA, equivalent of NICE has been gutted through deregulation and budget cuts in the U.S.A.. The Fox guards the hen house.

Comment by Stephen on November 10, 2016 at 9:19pm

If you allow it the drug company's would charge anything they could get away with.

In the UK we have an independent org called NICE (The National Institute for Health and Care Excellence) that makes a scientific and rational decision weather the NHS will buy any new drugs. not just on price but also on the effectiveness of the new drugs.

Comment by Chris on November 9, 2016 at 11:23am

FDA Concludes that Invokana Increases Risk of Osteoporosis

In addition to kidney damage, ketoacidosis and heart attacks, it turns out that canagliflozin – sold under the brand names Invokana and Invokamet – increases the risks of osteoporosis, or loss of bone density.

In clinical studies, elderly Type-2 diabetics treated with Invokana for two years or more showed reduced bone density in their lower spines and hips. While many people lose bone density as they get older, the recent studies show that treatment with Invokana can greatly accelerate the process. Some patients can suffer fractures in as little as three months after starting on the medication. Risks of bone loss and fractures were most pronounced in post-menopausal women.

The study, part of a post-marketing safety evaluation, continued for two years and involved more than 700 geriatric patients. According to a statement from the Food and Drug Administration (FDA) issued on September 10th, “The additional data confirm the finding that fractures occur more frequently with canagliflozin [Invokana] than placebo…fractures can occur as early as 12 weeks after starting the drug.”  Additional data was gathered from nine other clinical trials in which test subjects took the drug for an average of 85 weeks.

As a result of this new data, stronger warnings will be added to Invokana prescribing information.  The FDA is advising physicians to consider the risk of bone fractures before prescribing Invokana for their diabetic patients. In addition to Invokana, the FDA is monitoring similar medications in the class of SLGT2 inhibitors, or gliflozins.  These prescription drugs target a specific protein, known as sodium/glucose co-transporter 2. This protein is involved in the reabsorption of blood sugar (glucose) in the kidneys. SLGT2 inhibitors allow excess glucose to be passed in the urine. In addition to kidney damage, these drugs also increase the risk of urinary tract infections, vaginal yeast infections and dangerously low blood sugar levels (hypoglycemia). Other drugs in the gliflozin class include Farxiga (dapagliflozin), Jardiance (empagliflozin) and Glyxambia (linagliptin). All of these drugs will be under FDA scrutiny over the next several months.

Comment by Chris on November 9, 2016 at 11:20am

Silent Killer: Blood Thinner With No Antidote May Be Responsible fo...

For years Warfarin was the gold standard of blood thinners. Then the pharmaceutical industry saw an opportunity to make a profit by introducing new products. The products would promise the same or improved effectiveness with less hassle. Enter Xarelto, a blood thinner and anticoagulant that promises results with less administrative complication. The problem is that Xarelto has no antidote and patients may be dying because of it.

“Pharmaceutical companies, regrettably, have shown a tendency to put their own profits ahead of patient safety,” commented Ned McWilliams, a partner with the Levin Papantonio law firm. The Levin, Papantonio law firm is leading investigations into claims of injuries resulting from Xarelto.

Part of the marketing pitch for physicians to choose Xarelto over Warfarin hinges on the lower oversight requirements supposedly carried by the drug. According to the manufacturer, patients taking Xarelto require less surveillance by a physician. The argument is that Warfarin required constant monitoring to ensure that the levels of the drug in the patient’s blood didn’t get out of control.

If the saturation did get out of control though, often the only treatment that was necessary was to give patients a dose of Vitamin K to encourage clotting. Xarelto has no antidote. The manufacturer has yet to issue instructions to physicians about how to combat the problem of uncontrolled bleeding when it presents in patients as a result of Xarelto.

That problem of uncontrollable bleeding is what has patient advocates in arms over Xarelto. The product wasn’t needed; it solved a problem that didn’t need fixing. It has no antidote. The company that makes it has yet to publish guidelines for treating some of the most serious complications for treating the deadly side effects. And the company is making millions from the drug’s continued sale in the United States.

The only thing that can be done to treat an overdose of Xarelto, at this time, is to issue fresh plasma to the patient or wait for the drug to clear the blood. When the complication a patient is suffering from is hemorrhage or internal bleeding, that lack of an antidote may prove life-threatening.

Joshua is a writer and researcher with Ring of Fire. You can follow him on Twitter @Joshual33.

Comment by Chris on November 6, 2016 at 12:01am

TheraSpecs Migraine Relief Glasses: Do They Work?

The modern world of fluorescent lights and digital screens is inhospitable to people with light-triggered migraines. Let’s be real, it’s barely tolerable by the non-migrainey people. But for them, the lights and screens don’t trigger symptoms oppressive enough to keep them from working. If you have chronic migraine, vestibular or otherwise, these triggering light sources can mean a legitimate inability to work or even live a “normal” life.

When I began to slowly get back to work after being homebound for 10 months by my vestibular migraine and POTS symptoms, the computer screen issue became a real problem for me. And as I finally made my way back into a fluorescent light-laden office, that problem became unbearable. The lights weren’t just a nuisance, they were triggering my migraine symptoms and causing intense dizziness, vertigo, and head pressure. My first week back to full-time work absolutely destroyed me; my eyes just couldn’t take it!

So, I started looking into my options for ways to adapt. I needed something that could effectively block the offending lights from my sensitive eyeballs. Of course, one of the first things I came across were migraine relief glasses, specifically, those offered by the brand TheraSpecs. The concept behind these glasses is that they filter the wavelengths of blue-green light, like the ones in pulsating fluorescent lights, that are known to trigger migraines and headaches.

But before I pulled the trigger, I had a few questions I wanted answers to. Now that I’ve fallen in love with my pair, I’m writing this blog post to help others who may be waiting for those same answers to get themselves some relief!

...

More above

There is more to the above than the article depicts.

Comment by Chris on October 17, 2016 at 6:04am

Ring of Fire is an interesting broadcast that discusses pharmacutical and medical mishaps. Mike Papantonio who hosted RingOfFire apparently is moving on to a new program.

https://trofire.com/

Comment by Chris on October 14, 2016 at 8:16am

Something to keep in your first aid kit is Super Glue for Wound Closure.

We often get asked, especially on our Remote First Aid courses, if you can use Super Glue to close cuts? Yes it is perfectly possible to close wounds with glue but there is the legitimate clinical method and the 'have-a-go-Harry' approach with whatever Superglue comes to hand.  And there are subtle differences.

When treating our own injuries we take responsibility for our own actions.  When we are treating other people we have a Duty of Care to treat appropriately and cause no further harm or face the serious consequences of litigation.  For this reason we would not suggest that glue is used to treat casualties where you are in a position of responsibility be it your role within your workplace or providing opportunistic care for a casualty to have come across. 

You may still be inclined to use glue to treat yourself or maybe your trusted climbing partner, in which case, read on:

All Super Glues are not the same.

"Super Glue" or Cyanoacrylate (CA) is an acrylic resin which rapidly polymerises in the presence of water. The principle component of commercial CAs (SuperGlue, Krazy Glue, Loctite) is either methy-2-cyanoacrylate or ethyl-2-cyanoacrylate, the original forms of CA developed in 1942 by Kodak Laboratories. (The discovery was made whilst investigating potential, high clarity, acrylics for the use in gun sights. Whilst not suitable for this application CA was quickly identified as a fast acting, low shear strength adhesive.)


During the Vietnam war it was used in field surgery with good effect, however, despite the promising results it was not approved by the Unites States Food and Drug Administration due to the unknown toxicity and two significant side effects during the polymerization process:

  1. The curing process creates an exothermic reaction (heat) which can cause further tissue damage.
  2. The process releases cyanoacetate and formaldehyde - both irritants to the eyes, nose, throat and lungs.

Medical Glue

To overcome these harmful issues, new CAs were developed with the express purpose of use in surgery. 2-octyl cyanoacrylate (Derma+flex® QS™, SurgiSeal, FloraSeal and Dermabond) causes less skin irritation and increased flexibility and strength compared to traditional 'Super Glue'. In 1998 the US FDA approved 2-octyl cyanoacrylate for the closure of wounds and surgical incision and in 2001 was approved as "barrier against common bacterial microbes including certain staphylococci, pseudomonads, and Escherichia coli".

n-butyl cyanoacrylate wound adhesives are available under the trade names: LiquiBand®, Histoacryl, Indermil, GluStitch, GluShield, and Periacryl (dental adhesive)

Octyl ester, while providing a weaker bond, are more flexible. Butyl esters provide stronger bond, but are rigid.

 More Above.

Comment by Chris on September 24, 2016 at 4:50pm

Having the neurotoxin Botox injected into the scrotum for fun and ego may be a good reason to support tort reform

opposite of the common policy where patients are unable to even file a law suit against wacko doctors and pharmacutical companies.

Comment by Chris on September 22, 2016 at 1:40pm

There are some great plastic surgeons. Taking wrinkles out of scrotums just for the fun and money of of it doesn't qualify as appropriate use of medical resources. 

The wrinkles are there to keep the sperm 4-5 degrees below body temperature. A benifit to this may be that people who undergo scrotum dewrinkling surgery may become infertle. A vasectamy is a better option.

For what it's worth King louis XVI (1754-1793) was married with Marie Antoinette (in case you don't want to look at the following link.).  It's reported he had phimosis would have been a valid reason for forskin surgery called frenulopasty which isn't circumcision.

Circumcision is as inappropriate as labiaplasty.

Having the neurotoxin Botox injected into the scrotum for fun and ego may be a good reason to support tort reform.

 

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